Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain
F. Henot, E. Rioual, A. Favier, P. Macek, E. Crublet, P. Josso, B. Brutscher, M. Frech, P. Gans, C. Loison, J. Boisbouvier
The paper identifies a metastable excited state in the HSP90 ATP binding domain using solution NMR and mutagenesis, showing it transiently samples a closed state distant from the ground state.
bioRxiv · Mar 16, 2022 · PreprintBiophysics