Author

B. Brutscher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Organism:human· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Favier· 2 shared C. Loison· 1 shared D. Bourgeois· 1 shared E. Boeri Erba· 1 shared E. Crublet· 1 shared E. Pellegrini· 1 shared E. Rioual· 1 shared F. Henot· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

A. Favier

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3 papers

Recent·Most cited

Structural analysis shows that the BIR2 domain of E3 ligase XIAP binds across the RIP2 kinase dimer interface

M. Lethier, M. Hons, A. Favier, B. Brutscher, E. Boeri Erba, S. Cusack, E. Pellegrini

The paper determines the structure of the RIP2K-XIAP BIR2 complex, revealing its dimeric conformation and molecular mechanisms of interaction.

bioRxiv · Oct 14, 2022Biochemistry

Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain

F. Henot, E. Rioual, A. Favier, P. Macek, E. Crublet, P. Josso, B. Brutscher, M. Frech, P. Gans, C. Loison, J. Boisbouvier

The paper identifies a metastable excited state in the HSP90 ATP binding domain using solution NMR and mutagenesis, showing it transiently samples a closed state distant from the ground state.

bioRxiv · Mar 16, 2022 · PreprintBiophysics

NMR reveals light-induced changes in the dynamics of a photoswitchable fluorescent protein

B. Brutscher, N. E. Christou, I. Ayala, K. Giandoreggio-Barranco, M. Byrdin, V. Adam, D. Bourgeois

This study uses NMR to investigate light-induced conformational dynamics of rsFolder, a photoswitchable fluorescent protein, revealing dynamic changes that could inform future mutagenesis efforts.

bioRxiv · Jul 3, 2019Biophysics