P. Macek

Local nutrient addition drives plant biodiversity losses but not biotic homogenization in global grasslands

This study shows nutrient addition reduces plant diversity at local and larger scales equally, without causing biotic homogenization in global grasslands.

Deuteration of proteins boosted by cell lysates: high-resolution amide and Hα MAS NMR without re-protonation bottleneck

This paper demonstrates a method to overcome the re-protonation bottleneck in NMR by using deuterated cell lysates, enabling high-resolution amide and Hα MAS NMR with improved sensitivity.

Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain

The paper identifies a metastable excited state in the HSP90 ATP binding domain using solution NMR and mutagenesis, showing it transiently samples a closed state distant from the ground state.

Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR

The paper uses MAS NMR and computational methods to show a flexible loop in TET2 aminopeptidase is critical for catalytic function and substrate processing.

Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

The paper integrates NMR and cryo-EM to determine the atomic structure of a large enzyme complex, achieving high precision and accuracy beyond the limitations of each method individually.