SARS-CoV-2 Spike Protein Regulation of Angiotensin Converting Enzyme 2 and Tissue Renin-Angiotensin Systems: Influence of Biologic Sex
C. M. Ensor, Y. AlSiraj, R. Shoemaker, J. Sturgill, S. Keshavamurthy, E. Gordon, B. Dong, C. M. Waters, L. C. Cassis
This study examines how SARS-CoV-2 Spike protein affects ACE2 and RAS in lung and adipose tissues of male and female mice, revealing sex-specific differences in ACE2 expression and RAS activity.
bioRxiv · Sep 14, 2021 · PreprintPhysiology