B. Dong

Unleashing precision and freedom of optical manipulation: Software-aided real-time precision opto-control of intracellular molecular activities and cell functions

This paper introduces a software-assisted real-time optical manipulation platform for precise control of intracellular processes and cell functions.

Spectrally Resolved Localization Microscopy with Ultrahigh-Throughput

This paper develops an ultrahigh-throughput SMLM methodology using a color glass filter to achieve sub-10 nm localization and sub-5 nm spectral precision for multicolor imaging.

Quantification of cellular phototoxicity of organelle stains by the dynamics of microtubule polymerization

The paper quantifies early-stage phototoxicity of organelle stains by analyzing microtubule polymerization dynamics in live cells under different conditions.

Extracellular Matrix Abnormalities Contribute to Cardiac Insulin Resistance and Associated Dysfunction in Diet-induced Obese Mice

This study shows that ECM abnormalities contribute to cardiac insulin resistance and dysfunction in obese mice, with potential therapeutic implications.

IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing Type 2 immune responses

The paper identifies three HpARI family members in H. polygyrus bakeri, showing they have distinct effects on IL-33-dependent Type 2 immune responses.

Kin selection as a modulator of human handedness: sex-specific, parental and parent-of-origin effects

This study explores how kin selection influences human handedness, identifying sex-specific, parental, and parent-of-origin effects on handedness evolution.

Spatiotemporal precise optical manipulation of intracellular molecular activities

This paper develops a closed-loop optoelectronic system to precisely control molecular activities in live cells, demonstrating spatiotemporal manipulation of reactive oxygen species and tubulin polymerization.

Spatially-resolved single-cell atlas of ascidian endostyle provides insights into the origin of vertebrate pharyngeal organs

The paper constructs a spatially-resolved single-cell atlas of the ascidian endostyle, identifying new cell types and evolutionary insights into vertebrate pharyngeal organs.

SARS-CoV-2 Spike Protein Regulation of Angiotensin Converting Enzyme 2 and Tissue Renin-Angiotensin Systems: Influence of Biologic Sex

This study examines how SARS-CoV-2 Spike protein affects ACE2 and RAS in lung and adipose tissues of male and female mice, revealing sex-specific differences in ACE2 expression and RAS activity.

A bacterial genome and culture collection of gut microbial in weanling piglet

The paper establishes a bacterial genome and culture collection of the piglet gut microbiome, revealing new species and functional insights.

Heligmosomoides bakeri and Toxoplasma gondii co-infection leads to increased mortality associated with intestinal pathology

This study examines co-infection with Heligmosomoides bakeri and Toxoplasma gondii, finding increased mortality and intestinal pathology in co-infected mice.

Resolving Cargo-motor-track Interactions in Living Cells with Bifocal Parallax Single Particle Tracking

This paper introduces a bifocal parallax single particle tracking method to study 3D rotational and translational motion of cargo in living cells, revealing new interactions at microtubule intersections.

LRH-1 NUTRIGENOMICS: The Provision of Lauric Acid Results in the Endogenous Production of the Liver Receptor Homolog-1 Ligand, Dilauroylphosphatidylcholine, and LRH-1 Transactivation

This study shows that lauric acid intake leads to endogenous production of DLPC, an LRH-1 ligand, and enhances LRH-1 transcriptional activity in multiple tissues.

Casein Kinase 1G2 Suppresses Necroptosis-Promoted Testis Aging by Inhibiting Receptor-Interacting Kinase 3

This study shows that CSNK1G2 inhibits RIP3-mediated necroptosis, reducing testis aging in mice and conserved in humans.

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes

This study investigates how SARS-CoV-2 interacts with host antiviral pathways in respiratory and cardiac cells, finding it activates OAS-RNase L and PKR but not IFN, contrasting with MERS-CoV.

Oncogenic Activation of AKT by MAPK6

This study shows that MAPK6 activates AKT to promote cancer, leading to oncogenic outcomes and poor patient survival in multiple cancers.

Constitutive Androstane Receptor and Hepatitis B Virus X Protein Cooperatively Induce β-catenin-Activated Liver Tumors

This study shows that activating CAR with HBx in mice leads to liver tumors with strong β-catenin activation, mirroring human HBV-related HCC.

Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.

Deep learning enables structured illumination microscopy with low light levels and enhanced speed

This paper uses deep learning to improve structured illumination microscopy, reducing image requirements and enabling low-light, high-speed super-resolution imaging.

The host antiviral ribonuclease L protein supports Zika virus replication factory formation to enhance infectious virus production

This study shows RNase L supports ZIKV replication factory formation, enhancing infectious virus production, but inhibits other flaviviruses like dengue and West Nile.

Structural changes in the gut microbiome of short-term and long-term medical workers compared to normal controls

This study compares the gut microbiome of short-term and long-term medical workers to normal controls, finding significant structural changes linked to hospital exposure.