Author

C. M. Lugo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:deep learning· 1 Assay:electronic health records· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

L. H. Chao· 3 shared B. E. Luce· 2 shared J. L. McDonald· 2 shared P. Hakim· 2 shared S. Boopathy· 2 shared Y. Ge· 2 shared B. P. Kleinstiver· 1 shared B. Ueberheide· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiophysics

L. H. Chao

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification of SLC25A46 interaction interfaces with mitochondrial membrane fusogens Opa1 and Mfn2

S. Boopathy, B. E. Luce, C. M. Lugo, P. Hakim, J. L. McDonald, H. L. Kim, J. Ponce, B. Ueberheide, L. H. Chao

This study identifies interaction interfaces between SLC25A46 and mitochondrial fusion proteins Opa1 and Mfn2 using crosslinking mass-spectrometry and AlphaFold 2 modeling.

Journal of Biological Chemistry · Oct 1, 2024Peer-reviewedBiochemistry

In situ architecture of Opa1-dependent mitochondrial cristae remodeling

M. Y. Fry, P. P. Navarro, P. Hakim, V. Y. Ananda, X. Qin, J. C. Landoni, S. Rath, Z. Inde, C. M. Lugo, B. E. Luce, Y. Ge, J. L. McDonald, I. Ali, L. L. Ha, B. P. Kleinstiver, , L. H. Chao

This study uses cryo-electron tomography to visualize how different Opa1 forms affect mitochondrial cristae architecture and function in mouse cells.

bioRxiv · Jan 16, 2023 · PreprintBiophysics

Absence of cardiolipin from the outer leaflet of a mitochondrial inner membrane mimic restricts Opa1-mediated fusion

Y. Ge, S. Boopathy, T. H. Nguyen, C. M. Lugo, L. H. Chao

The paper investigates how cardiolipin distribution affects mitochondrial inner membrane fusion mediated by Opa1, finding that cardiolipin in the outer leaflet is crucial for tethering and fusion.

bioRxiv · Sep 1, 2021Biophysics