Author

P. Hakim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

B. E. Luce· 3 shared L. H. Chao· 3 shared A. G. Vecchiarelli· 2 shared C. M. Lugo· 2 shared J. L. McDonald· 2 shared V. Y. Ananda· 2 shared A. Monshizadeh· 1 shared B. P. Kleinstiver· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

B. E. Luce

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Identification of SLC25A46 interaction interfaces with mitochondrial membrane fusogens Opa1 and Mfn2

S. Boopathy, B. E. Luce, C. M. Lugo, P. Hakim, J. L. McDonald, H. L. Kim, J. Ponce, B. Ueberheide, L. H. Chao

This study identifies interaction interfaces between SLC25A46 and mitochondrial fusion proteins Opa1 and Mfn2 using crosslinking mass-spectrometry and AlphaFold 2 modeling.

Journal of Biological Chemistry · Oct 1, 2024Peer-reviewedBiochemistry

Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation

T. A. Bell, B. E. Luce, P. Hakim, V. Y. Ananda, H. Dardari, T. H. Nguyen, A. Monshizadeh, L. H. Chao

This study shows that Prom1 and Ttyh1 both induce extracellular vesicle formation, with Ttyh1 producing more tubulated vesicles and showing stronger cholesterol binding.

bioRxiv · Nov 8, 2023Biochemistry

In situ architecture of Opa1-dependent mitochondrial cristae remodeling

M. Y. Fry, P. P. Navarro, P. Hakim, V. Y. Ananda, X. Qin, J. C. Landoni, S. Rath, Z. Inde, C. M. Lugo, B. E. Luce, Y. Ge, J. L. McDonald, I. Ali, L. L. Ha, B. P. Kleinstiver, , L. H. Chao

This study uses cryo-electron tomography to visualize how different Opa1 forms affect mitochondrial cristae architecture and function in mouse cells.

bioRxiv · Jan 16, 2023 · PreprintBiophysics

Dissection of the ATPase active site of McdA reveals the sequential steps essential for carboxysome distribution

P. Hakim, A. G. Vecchiarelli

This study identifies key steps in the ATPase cycle of McdA that drive carboxysome distribution by trapping McdA at specific ATP cycle stages and mapping its interactions with DNA and McdB-bound carboxysomes.

bioRxiv · Apr 2, 2021Microbiology

The McdAB system positions α-carboxysomes in proteobacteria

J. S. MacCready, L. Tran, J. L. Basalla, P. Hakim, A. G. Vecchiarelli

The paper shows that the McdAB system positions α-carboxysomes in proteobacteria, distinct from its role in cyanobacteria, and suggests horizontal transfer of the system from proteobacteria to cyanobacteria.

bioRxiv · Aug 11, 2020Microbiology