X. Qin

Dehydrozaluzanin C- derivative protects septic mice by alleviating over-activated inflammatory response and promoting the phagocytosis of macrophages

DHZD reduces inflammation and enhances macrophage phagocytosis in septic mice, showing potential as an HDT agent for bacterial infections.

SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

SIGNAL-seq: Multimodal Single-cell Inter- and Intra-cellular Signalling Analysis

SIGNAL-seq measures RNA and PTMs in single cells to analyze inter- and intra-cellular signaling in the tumor microenvironment.

A functional medicine and food homology composition discovery based on disease-related target and data mining against cardiac remodeling

This study identifies β-ecdysterone as a functional compound that counteracts cardiac remodeling by enhancing NRF2, revealing cross-talk between cardiac remodeling and neuromodulation.

The role of alternative polyadenylation in Epithelial-mesenchymal transition of non-small cell lung cancer

This study identifies alternative polyadenylation (APA) events in non-small cell lung cancer (NSCLC) that influence EMT and drug response, showing shorter 3-UTRs correlate with better chemotherapy outcomes.

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Alterations in Epithelial Integrity

This study uses scRNA-seq to analyze DCIS and normal breast tissue, identifying clonal heterogeneity and cell state changes associated with progression to invasive cancer.

Tumors cells with mismatch repair deficiency induce hyperactivation of Pyroptosis resistant to cell membrane damage but are more sensitive to Co-treatment of IFN-γ and TNF-α to PANoptosis

The paper shows that dMMR tumor cells are resistant to membrane damage but sensitive to IFN-γ and TNF-α co-treatment inducing PANoptosis, suggesting a strategy to enhance ICB therapy.

Functional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea

The paper investigates E. coli strains from cancer patients with diarrhea, finding novel adherence patterns and high antibiotic resistance gene carriage.

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

Dynamics of the epigenetic landscape during development and in response to drought stress in sorghum

This study identifies novel epigenomic features in sorghum, including H3K27me3 islands and the role of histone marks in regulating tissue-specific and stress-responsive genes.

A Single-cell Perturbation Landscape of Colonic Stem Cell Polarisation

The paper maps how oncogenic mutations and microenvironmental signals co-regulate colonic stem cell fate through single-cell analysis of organoid cultures.

In situ architecture of Opa1-dependent mitochondrial cristae remodeling

This study uses cryo-electron tomography to visualize how different Opa1 forms affect mitochondrial cristae architecture and function in mouse cells.

iTie controls intestinal tolerance through suppressing the NLRP6 inflammasome

This study identifies iTie as a regulator of intestinal tolerance by suppressing the NLRP6 inflammasome, with implications for treating bowel diseases.

Trellis Single-Cell Screening Reveals Stromal Regulation of Patient-Derived Organoid Drug Responses

The paper develops Trellis, a method to analyze single-cell drug responses in PDOs and CAFs, revealing patient-specific apoptosis and CAF-mediated chemoprotection via YAP signaling.

Single-cell Landscape Analysis Unravels Molecular Programming of the Human B Cell Compartment in Chronic GVHD

This study uses scRNA-Seq to analyze B cells from allo-HCT patients, revealing molecular differences in B cell subsets associated with active versus non-active cGVHD.

Treg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma

This study shows Treg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma using human and zebrafish models.

LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

This study shows LKB1 suppresses JNK-dependent stress signaling in KRAS-mutant lung cancers, revealing a therapy-induced vulnerability that could improve KRAS-targeted therapies.

MAL suppresses OSCC tumorigenesis by maintaining epithelial cell differentiation

This study shows MAL suppresses OSCC by maintaining epithelial differentiation, with MAL and its co-functional genes as potential biomarkers for prevention and therapy.

A systematic CRISPR screen reveals an IL-20/IL20RA-mediated peritoneal immune crosstalk to prevent the ovarian cancer metastasis

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

Development and Application of Cas13a-based Diagnostic Assay for Neisseria Gonorrhoeae Detection and Identification of Azithromycin Resistance

This paper develops a Cas13a-based assay for detecting Neisseria gonorrhoeae and identifying azithromycin resistance mutations, showing high sensitivity and concordance with existing methods.

APOBEC mutagenesis inhibits breast cancer growth through induction of a T cell-mediated antitumor immune response

This study shows that APOBEC mutagenesis in breast cancer promotes T cell-mediated antitumor immunity, leading to tumor growth inhibition and sensitivity to checkpoint inhibitors.

Activation of Notch1 drives the development of radiation-induced thymic lymphoma in p53 wild-type mice

This study identifies Notch1 activation as a key driver of radiation-induced thymic lymphoma in p53 wild-type mice through genomic and functional analyses.

Characterization of a novel gene, srpA, conferring resistance to streptogramin A, pleuromutilins, and lincosamides in Streptococcus suis

This study identifies a novel gene, srpA, in Streptococcus suis that confers resistance to multiple ribosome-targeting antibiotics by altering ribosome binding.

Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production

This study shows that ITGB4 in airway epithelial cells reduces CCL17 production, thereby suppressing Th2 responses and allergic inflammation in asthma.

Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lens

This paper introduces a new variant of oblique plane microscopy (OPM) that achieves a large mesoscopic field-of-view for volumetric imaging, demonstrating its application on zebrafish larvae, mouse cortex, and C. elegans.

Acute Respiratory Distress and Cytokine Storm in Aged, SARS-CoV-2 Infected African Green Monkeys, but not in Rhesus Macaques

This study compares SARS-CoV-2 infection in aged African green monkeys and rhesus macaques, finding ARDS and cytokine storms in AGMs but not RMs.

Novel ACE2-IgG1 fusions with improved in vitro and in vivo activity against SARS-CoV2

This paper develops a modified ACE2-IgG1 fusion protein with enhanced in vivo activity against SARS-CoV2, showing improved lung bioavailability and viral neutralization.

A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy

The paper compares immune landscapes in transplant and primary tumors after immunotherapy and radiotherapy, finding that transplant tumors respond better due to CD8+ T cell enrichment.

Single-Cell Signalling Analysis of Heterocellular Organoids

This study uses mass cytometry to analyze cell-type specific signaling networks in organoids and reveals how genetic mutations mimic stromal cell signaling in cancer organoids.

APOC2 accelerates colorectal cancer progression via modulating lipid metabolism and transcriptional activity of PHF8

This study shows APOC2 promotes colorectal cancer by altering lipid metabolism and activating PHF8 transcription, linking it to poor prognosis.