An Epitope-Focused Trypanosome-Derived Vaccine Platform Elicits High-Affinity Antibodies and Immunity Against Fentanyl Effects
G. Triller, E. P. Vlachou, H. Hashemi, M. van Straaten, J. Zeelen, Y. Kelemen, C. Baehr, C. Marker, S. Ruf, A. Svirina, S. Kruse, A. Baumann, A. Miller, M. Bartel, M. Pravetoni, , J. P. Verdi
This paper develops a trypanosome-derived vaccine platform (VAST) that elicits high-affinity antibodies against fentanyl, demonstrating protective immunity through single-cell RNAseq and crystallography.
bioRxiv · May 2, 2022 · PreprintImmunology