Author

C. Nian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

F. C. Lynn· 3 shared H. Winata· 2 shared S. Sasaki· 2 shared D. J. Pasula· 1 shared D. S. Luciani· 1 shared D. Zhang· 1 shared E. E. Xu· 1 shared J. S. Yoon· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersPhysiology

F. C. Lynn

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Calcium-dependent transcriptional profiles of human pancreatic islet cells reveal functional diversity in islet subpopulations

J. S. Yoon, S. Sasaki, J. Velghe, K. Zosel, M. Y. Y. Lee, H. Winata, C. Nian, F. C. Lynn

The paper profiles calcium-regulated gene expression in human pancreatic islet cells using single-cell RNA sequencing and identifies PCDH7 as a novel beta cell marker with enhanced insulin secretory function.

bioRxiv · Sep 8, 2023 · PreprintPhysiology

Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5 in mice

S. Sasaki, C. Nian, E. E. Xu, D. J. Pasula, H. Winata, S. Grover, D. S. Luciani, F. C. Lynn

This study identifies GRK5 as a regulator of pancreatic β-cell proliferation through phosphorylation of HDAC5, linking it to type 2 diabetes pathogenesis.

iScience · Aug 1, 2023Peer-reviewedPhysiology

Truncated CD19 as a selection marker for the isolation of stem cell derived β-cells

L. T. H. Huang, D. Zhang, C. Nian, F. C. Lynn

This study uses CRISPR/Cas9 to knock-in CD19-mScarlet in hESCs to enrich insulin-expressing SC{beta}-cells through magnetic sorting, improving glucose-stimulated c-peptide secretion.

bioRxiv · Apr 5, 2023Bioengineering