Author

D. J. Pasula

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. S. Luciani· 3 shared B. Hoffman· 2 shared B. Vanderkruk· 2 shared F. C. Lynn· 2 shared A. Chaudhry· 1 shared A. Z. L. Shih· 1 shared C. L. McDonald· 1 shared C. Nian· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

D. S. Luciani

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3 papers

Recent·Most cited

Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5 in mice

S. Sasaki, C. Nian, E. E. Xu, D. J. Pasula, H. Winata, S. Grover, D. S. Luciani, F. C. Lynn

This study identifies GRK5 as a regulator of pancreatic β-cell proliferation through phosphorylation of HDAC5, linking it to type 2 diabetes pathogenesis.

iScience · Aug 1, 2023Peer-reviewedPhysiology

Bcl-xL restricts transcriptional, morphological and functional decompensation of β-cell mitochondria under chronic glucose excess

D. J. Pasula, R. Shi, B. Vanderkruk, A. Z. L. Shih, Y. Zou, A. Chaudhry, B. Hoffman, D. S. Luciani

This study shows that Bcl-xL prevents mitochondrial dysfunction in beta-cells under chronic glucose stress by limiting mitochondrial ROS and maintaining gene expression.

bioRxiv · Oct 25, 2021 · PreprintCell Biology

Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice

B. Vanderkruk, N. Maeshima, D. J. Pasula, M. An, C. L. McDonald, F. C. Lynn, D. S. Luciani, B. Hoffman

This study shows that H3K4me3 is essential for maintaining beta cell function in adult mice by supporting gene expression for insulin biosynthesis and glucose responsiveness.

bioRxiv · Jan 28, 2021Cell Biology