Author

C. O'Shea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein design· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. R. Winther· 2 shared K. E. Johansson· 2 shared K. Lindorff-Larsen· 2 shared A. D. Grassam-Rowe· 1 shared A. M. Ibrahim· 1 shared C. Pallini· 1 shared D. A. Terrar· 1 shared D. Pavlovic· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

J. R. Winther

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Generation of cardiomyocytes from human induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonists

F. S. Ahmad, Y. Jin, A. D. Grassam-Rowe, Y. Zhou, M. Yuan, X. Fan, R. Zhou, R. Mu-u-min, C. O'Shea, A. M. Ibrahim, W. Hyder, Y. Aguib, M. Yacoub, D. Pavlovic, Y. Zhang, , M. Lei

This paper describes a method to generate human atrial-like cardiomyocytes from induced pluripotent stem cells that respond to adrenoceptor agonists.

bioRxiv · Jul 20, 2022 · PreprintBioengineering

Increasing protein stability by inferring substitution effects from high-throughput experiments

R. K. Norrild, K. E. Johansson, C. O'Shea, J. P. Morth, K. Lindorff-Larsen, J. R. Winther

The paper uses a computational model to infer substitution effects from high-throughput experiments, increasing protein stability through targeted amino acid changes.

bioRxiv · May 18, 2022Biochemistry

Computational and experimental assessment of backbone templates for computational protein design

F. I. Marin, K. E. Johansson, C. O'Shea, K. Lindorff-Larsen, J. R. Winther

The paper assesses computational protein design templates using Rosetta Design and experimental validation, finding that the cart_bonded energy term improves template selection for successful designs.

bioRxiv · Jun 23, 2021Biochemistry

Immobilised collagen prevents shedding and induces sustained GPVI clustering and signalling in platelets.

C. Pallini, J. A. Pike, C. O'Shea, R. K. Andrews, E. E. Gardiner, S. P. Watson, N. S. Poulter

This study shows immobilized collagen prevents GPVI shedding and sustains its clustering and signaling in platelets for at least 3 hours.

bioRxiv · Jul 7, 2020 · PreprintCell Biology