In lupus nephritis, specific in situ inflammatory states are associated with refractory disease and progression to renal failure
R. Abraham, M. S. Durkee, J. Ai, M. Veselits, G. Casella, Y. Asano, A. Chang, K. Ko, C. Oshinsky, E. Peninger, M. Giger, M. R. Clark
Using deep machine learning to analyze confocal microscopy data, the study shows CD4-T cell populations in lupus nephritis organize into spatial neighborhoods predicting renal failure progression.
bioRxiv · Sep 3, 2021 · PreprintImmunology