A. Chang

Metabolic regulation of misfolded protein import into mitochondria

This study shows that Snf1/AMPK inhibits misfolded protein import into mitochondria and promotes mitochondrial biogenesis under glucose starvation, protecting mitochondrial fitness in yeast and human cells.

Potent neutralization by a receptor binding domain monoclonal antibody with broad specificity for SARS-CoV-2 JN.1 and other variants

This study develops a monoclonal antibody that broadly neutralizes multiple SARS-CoV-2 variants, including JN.1, and shows its protective efficacy in mice.

Studies of DNA "breathing" by polarization-sweep single-molecule fluorescence microscopy of exciton-coupled (iCy3)2 dimer-labeled DNA fork constructs

This paper introduces a single-molecule fluorescence method to measure DNA breathing dynamics using (iCy3)2 dimer probes, revealing four conformational macrostates in DNA fork constructs.

Impact of age and sex on neuroinflammation following SARS-CoV-2 infection in a murine model

This study examines how age and sex influence neuroinflammation after SARS-CoV-2 infection in mice, finding that males and older animals show greater weight loss, viral load, and immune response, while no virus was detected in the brain.

De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

This paper designs highly selective miniprotein inhibitors for integrins αvβ6 and αvβ8 with picomolar affinity and therapeutic potential in a mouse fibrosis model.

Automatic Abdominal Multi Organ Segmentationusing Residual UNet

This paper develops a residual UNet model for abdominal multi-organ segmentation using CT and MRI scans, achieving high Dice scores in held-out tests.

Automatic Whole Body FDG PET/CT Lesion Segmentation using Residual UNet and Adaptive Ensemble

The paper develops a deep learning method using residual UNET and adaptive ensemble for automated FDG PET/CT lesion segmentation, achieving a dice score of 0.5541 on a test dataset.

Breathe Easy, an automated respiratory data pipeline for waveform characteristic analysis

Breathe Easy automates respiratory data analysis, producing statistical outputs and graphs, validated against manual methods in an Alzheimer's mouse model.

Discovery of prevalent, clinically actionable tumor neoepitopes via integrated biochemical and cell-based platforms

The paper identifies 84 clinically relevant neoepitope-HLA pairs from 37 shared cancer neoantigens using a combination of biochemical assays and computational methods.

Machine learning-based classification of binary dynamic fluorescence signals reveals muscle stem cell fate transitions in response to pro-regenerative niche factors

This study uses machine learning to analyze dynamic fluorescence signals and classify muscle stem cell fate transitions in response to niche factors like PGE2 and OSM.

Caenorhabditis nematodes colonize ephemeral resource patches in neotropical forests.

The paper investigates Caenorhabditis nematode species composition and colonization dynamics in tropical forests, finding globally distributed androdiecious species dominate and colonization occurs via phoresy with low founder numbers.

Upregulated PD-1 Signaling is an Important Antagonist to Glomerular Health in Aged Kidneys

This study shows that upregulated PD-1 signaling in aged kidneys impairs podocyte health and that anti-PD-1 treatment improves podocyte aging and kidney function.

Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery Against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques

This study evaluates the protective efficacy of oral SARS-CoV-2 delivery in rhesus macaques against respiratory challenges, finding limited immunogenicity and partial protection.

An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice

This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.

In lupus nephritis, specific in situ inflammatory states are associated with refractory disease and progression to renal failure

Using deep machine learning to analyze confocal microscopy data, the study shows CD4-T cell populations in lupus nephritis organize into spatial neighborhoods predicting renal failure progression.

Screening of cell-virus, cell-cell, gene-gene interactions among kingdoms of life at single cell resolution

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates

This paper describes a protein subunit vaccine candidate produced in yeast that protects non-human primates against SARS-CoV-2, showing high neutralizing antibody titers and reduced viral loads after challenge.

Protective efficacy of rhesus adenovirus COVID-19 vaccines against mouse-adapted SARS-CoV-2

This study evaluates the protective efficacy of rhesus adenovirus serotype 52 vaccines against a mouse-adapted SARS-CoV-2 strain, showing robust antibody responses and protection against viral replication and disease.

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis

This study analyzes the roles of two Mg2+ ions in DNA polymerase specificity and catalysis using kinetic analysis and molecular dynamics simulations.

Intrarenal B cells integrate in situ innate and adaptive immunity in human renal allograft rejection

The paper identifies a unique B cell subset in renal allograft rejection that contributes to local inflammation through self-reactive antibodies and innate-like signaling.

Expression of Tim-3 drives naive Treg to an effector-like state with enhanced suppressive activity

The paper shows that Tim-3 expression in Treg cells drives them to an effector-like state with enhanced suppressive activity, promoting tumor growth.

In situ humoral selection in human lupus tubulointerstitial inflammation

The paper shows that anti-vimentin antibodies in lupus nephritis undergo in situ selection for enhanced binding and specificity to vimentin fibrils, challenging the notion of affinity maturation as a non-specific consequence of polyreactivity.

Separation of Bioactive Small Molecules, Peptide from Natural Products and Proteins from Pathogenic Microbe by Rotofor-based Preparative Isoelectric Focusing (IEF) Method

This paper introduces a Rotofor-based IEF method for separating bioactive small molecules, peptides, and proteins from complex samples, demonstrating its effectiveness with plant extracts and microbial proteins.

Unoccupied aerial system enabled functional modeling of maize (Zea mays L.) height reveals dynamic expression of loci associated to temporal growth.

This paper uses UAS to model maize growth and identifies temporal QTL associated with plant height, showing dynamic expression patterns over time.

Myosin-II mediated traction forces evoke localized Piezo1 Ca2+ flickers

The paper shows that Myosin-II mediated traction forces cause localized Piezo1 Ca2+ flickers in cells without external forces.

Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphoma

This paper shows that HDAC3 inhibitors reverse CREBBP mutation-driven epigenetic changes in lymphoma, inhibiting tumor growth and restoring immune surveillance.

Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine already linked to neuronal damage

This study identifies CXCL10 as a key biomarker of acute Zika virus infection through analysis of cytokine and chemokine levels in infected patients.