Author

C. Patrick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Lucas· 3 shared K. Mallela· 3 shared V. Upadhyay· 3 shared J. N. Weitzel· 2 shared S. L. Neuhausen· 2 shared Y. C. Ding· 2 shared A. Adamson· 1 shared A. M. Napoles· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

A. Lucas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Biophysical evolution of the receptor binding domains of SARS-CoVs

V. Upadhyay, S. Panja, A. Lucas, C. Patrick, K. Mallela

This study compares the biophysical properties of SARS-CoV and SARS-CoV-2 receptor binding domains, finding differences in stability, aggregation, and ACE2 binding affinity.

bioRxiv · Jun 13, 2023Biophysics

Profile of the somatic mutational landscape in breast tumors from Hispanic/Latina women

Y. C. Ding, H. Song, A. Adamson, D. Schmolze, D. Hu, S. Huntsman, L. Steele, C. Patrick, N. Hernandez, C. D. Adams, L. Fejerman, K. L. Gardner, A. M. Napoles, E. J. Perez-Stable, J. N. Weitzel, , E. Ziv

This study analyzes the somatic mutational landscape of breast tumors in Hispanic/Latina women using whole-exome and RNA-seq, identifying common mutations and novel mutation signatures.

bioRxiv · Aug 1, 2022 · PreprintCancer Biology

Variable Number Tandem Repeats (VNTRs) as modifiers of breast cancer risk in carriers of BRCA1 185delAG

Y. C. Ding, A. W. Adamson, M. Bakhtiari, C. Patrick, J. Park, Y. Laitman, J. N. Weitzel, V. Bafna, E. Friedman, S. L. Neuhausen

This study identifies VNTRs as modifiers of breast cancer risk in BRCA1 185delAG carriers, finding several VNTRs significantly associated with earlier age of onset compared to SNPs.

bioRxiv · Jun 1, 2022Cancer Biology

Biophysical fitness landscape of the SARS-CoV-2 Delta variant receptor binding domain

C. Patrick, V. Upadhyay, A. Lucas, K. Mallela

This study examines how biophysical properties of the Delta variant's RBD correlate with clinical outcomes, finding that L452R mutation drives immune escape rather than receptor binding.

bioRxiv · Feb 21, 2022Biophysics

Convergent evolution of multiple mutations improves the viral fitness of SARS-CoV-2 variants by balancing positive and negative selection

V. Upadhyay, C. Patrick, A. Lucas, K. Mallela

The paper examines how convergent mutations in SARS-CoV-2 variants balance positive and negative selection to enhance viral fitness.

bioRxiv · Dec 23, 2021Biophysics