A. Lucas

Piximi - An Images to Discovery web tool for bioimages and beyond

Piximi provides a no-programming web tool for biological image analysis using deep learning, enabling rapid insights without installation or coding.

kMermaid: Ultrafast functional classification of microbial reads

kMermaid provides an ultrafast and accurate method for classifying metagenomic reads into functional protein clusters, improving upon existing methods with lower computational demands.

Biophysical evolution of the receptor binding domains of SARS-CoVs

This study compares the biophysical properties of SARS-CoV and SARS-CoV-2 receptor binding domains, finding differences in stability, aggregation, and ACE2 binding affinity.

Biophysical fitness landscape of the SARS-CoV-2 Delta variant receptor binding domain

This study examines how biophysical properties of the Delta variant's RBD correlate with clinical outcomes, finding that L452R mutation drives immune escape rather than receptor binding.

Convergent evolution of multiple mutations improves the viral fitness of SARS-CoV-2 variants by balancing positive and negative selection

The paper examines how convergent mutations in SARS-CoV-2 variants balance positive and negative selection to enhance viral fitness.

Interplay between receptor binding, immune escape and protein stability determines the natural selection of SARS-CoV-2 variants

The paper evaluates how mutations in SARS-CoV-2's receptor binding domain affect protein stability, ACE2 binding, and antibody escape, showing multiple factors influence variant selection.

Robotic Stereotaxic System based on 3D skull reconstruction to improve surgical accuracy and speed

This paper introduces a robotic stereotaxic system using 3D skull reconstruction to enhance the accuracy and speed of small-animal brain surgeries while reducing experimental failure rates.