D. Hu

Cell division protein A (CdpA) organises and anchors the division ring at midcell in haloarchaea

This study identifies CdpA as a protein involved in organizing and anchoring the division ring in Haloferax volcanii, showing its role in stabilizing FtsZ proteins during cell division.

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

ApoE ε4-dependent alteration of CXCR3+CD127+ CD4+ T cells is associated with elevated plasma neurofilament light chain in Alzheimer's disease

The paper finds that ApoE ε4-dependent changes in CXCR3+CD127+ CD4+ T cells in peripheral blood correlate with elevated neurofilament light chain in Alzheimer's disease.

Cyclical transcription factor AP2XII-9 is a key activator for asexual division and apicoplast inheritance in Toxoplasma gondii tachyzoite

This study identifies TgAP2XII-9 as a critical S/M-phase transcription factor regulating endodyogeny and apicoplast inheritance in Toxoplasma gondii tachyzoites.

Cure or Curse? Simulation Indicates that Microbes Proliferate under Disinfection Measures in the Space Station

This study simulates microbial proliferation in the space station under disinfection measures and finds that factors like low-dose ionizing radiation, dilution, and quaternary ammonium compound can synergistically promote microbial growth.

Bacillus velezensis HBXN2020 alleviates Salmonella Typhimurium infection in mice by improving intestinal barrier integrity and reducing inflammation

This study shows that Bacillus velezensis HBXN2020 reduces Salmonella Typhimurium infection in mice by enhancing intestinal barrier function and decreasing inflammation.

Acquisition of Auditory Discrimination Mediated by Different Processes through Two Distinct Circuits Linked to the Lateral Striatum

This study shows that different striatal subregions, aDLS and pVLS, use distinct processes to mediate auditory discrimination learning in rats.

CD81 represses NF-?B in HCV-expressing hepatoma cells

This study identifies CD81 as a negative regulator of NF-κB signaling in HCV-expressing hepatoma cells, showing that its downregulation enhances NF-κB activity and promotes cell growth.

Second Harmonic Generation Imaging Reveals Entanglement of Collagen Fibers in the Elephant Trunk Skin Dermis

The paper uses second harmonic generation microscopy to analyze collagen fiber organization in elephant trunk skin, revealing a bimodal distribution and entanglement that enables both flexibility and strength.

Tetherin restricts SARS-CoV-2 replication despite antagonistic effects of Spike and ORF7a

This study shows that SARS-CoV-2 S and ORF7a antagonize Tetherin, but Tetherin still restricts SARS-CoV-2 replication.

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

This study shows JMJD6 links pre-mRNA splicing and metabolism in MYC-driven cancers, and its inhibition enhances therapeutic response to splicing inhibitors.

Genomic epidemiology and multilevel genome typing of Bordetella pertussis

This paper introduces a multilevel genome typing system for Bordetella pertussis to improve surveillance and understanding of circulating strains and their public health risks.

Emergence of rhythmic chunking in complex stepping of mice

This study identifies rhythmic chunking in mice stepping, showing consistent cycle and phase patterns within chunks and linking licking behavior to these rhythms.

Social Isolation Causes Cortical and Trabecular Bone Loss in Adult Male, but not Female, C57BL/6J Mice

This study shows social isolation causes bone loss in male, but not female, mice, with different molecular mechanisms in each sex.

Kinetic model derivation for design, building and operation of solid waste treatment unit based on system dynamics and computer simulation

This paper develops a kinetic model for solid waste treatment units using system dynamics and simulation, demonstrating its validity through a 370-day experiment with a prototype.

Transgressive and parental dominant gene expression and cytosine methylation during seed development in Brassica napus hybrids

The paper identifies transgressive and parental dominant gene expression and methylation patterns in Brassica napus hybrids during seed development, linking them to early heterosis mechanisms.

Profile of the somatic mutational landscape in breast tumors from Hispanic/Latina women

This study analyzes the somatic mutational landscape of breast tumors in Hispanic/Latina women using whole-exome and RNA-seq, identifying common mutations and novel mutation signatures.

Genomic dissection of the microevolution of Australian epidemic Bordetella pertussis

This study analyzes the genomic and phylogeographic dynamics of B. pertussis in Australia, revealing lineage expansion, selective sweeps, and spatial spread patterns linked to vaccination and transmission.

Digital restoration of the pectoral girdles of two Early Cretaceous birds, and implications for early flight evolution

The paper digitally reconstructs pectoral girdles of two Early Cretaceous birds, revealing morphological features and their implications for early flight evolution.

Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Dextran Sodium Sulfate-Induced Ulcerative Colitis

This study shows that Celastrol reduces colitis by modulating gut microbiota, improving immune balance, and increasing metabolites like pyruvate and adenosine.

Research productivity and collaboration of the NIH-funded HIV Vaccine Trials Network: a bibliometric analysis

This paper analyzes the scientific productivity and collaboration of the HIV Vaccine Trials Network (HVTN) over two decades using bibliometric methods, finding high-impact publications and increased collaboration.

KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

This study shows KDM6B promotes oncogenic CDK4/6-pRB-E2F pathway activation in neuroblastoma by maintaining enhancer activity, and its inhibition correlates with poor patient survival.

A fast numerical method for oxygen supply in tissue with complex blood vessel network

The paper introduces a fast numerical method for simulating oxygen supply in tissue with complex blood vessel networks, achieving accurate results efficiently.

The Profiling of Bisecting N-acetylglucosamine (GlcNAc) Modification in Human Amniotic Membrane by Glycomic and Glycoproteomic Analyses

This paper identifies and profiles bisecting N-acetylglucosamine modifications in human amniotic membrane through glycomic and glycoproteomic analyses, revealing 41 glycoproteins with this modification.

Paxillin Promotes ATP-induced Activation of P2X7 Receptor and NLRP3 Inflammasome

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

Pharmacological inhibition of longevity regulator PAPP-A restrains mesenchymal stromal cell activity

This study shows that inhibiting PAPP-A reduces collagen and ECM gene expression and modulates mesenchymal stromal cell activity in mice.

Germline genetic contribution to the immune landscape of cancer

This study identifies germline genetic variants associated with immune traits in cancer, revealing their impact on the tumor immune microenvironment.

Remodeling gut microbiota by Streptococcus thermophilus 19 attenuates inflammation in septic mice

This study shows that S. thermophilus 19 reduces inflammation in septic mice by remodeling gut microbiota.

A Holistic Analysis of the Intestinal Stem Cell Niche Network

The paper analyzes the intestinal stem cell niche by combining bulk RNA sequencing and scRNA-seq to identify a network of cell types and signals involved in ISC regulation.

A method of back-calculating the log odds ratio and standard error of the log odds ratio from the reported group-level risk of disease

The paper presents a method to calculate the log odds ratio and its standard error from group-level disease risk estimates, demonstrating its superiority in standard error calculation compared to existing methods.