Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment
W. Kerr, S. Fernandes, N. Srivastava, C. Pedicone, R. Sudan, E. Luke, O. Dungan, A. Pacherille, S. T. Meyer, S. Dormann, J. D. Chisholm
This study shows that pan-SHIP1/2 inhibition prevents diet-induced obesity and improves glucose regulation, but requires eosinophils for fat reduction and acts via the VAT immune compartment.
bioRxiv · Sep 15, 2020Immunology