ImmunologybioRxiv
Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment
W. Kerr, S. Fernandes, N. Srivastava…·J. D. Chisholm
This study shows that pan-SHIP1/2 inhibition prevents diet-induced obesity and improves glucose regulation, but requires eosinophils for fat reduction and acts via the VAT immune compartment.
DOI 10.1016/j.isci.2023.106071