Cancer BiologybioRxivPreprint
Loss of RNF43/ZNRF3 predisposes to Hepatocellular carcinoma by impairing liver regeneration and altering liver fat metabolism
G. Mastrogiovanni, C. Pacini, S. Kakava…·M. Huch
This study shows that loss of RNF43/ZNRF3 leads to liver cancer by disrupting lipid metabolism and impairing liver regeneration in mice, with similar effects observed in human patients.