Pharmacology & ToxicologybioRxiv
A subtle structural modification of a synthetic cannabinoid receptor agonist drastically increases its efficacy at the CB1 receptor
H. Yano, R. Chitsazi, C. Lucaj…·L. Shi
This study identifies a structural modification in a synthetic cannabinoid receptor agonist that significantly increases its efficacy at the CB1 receptor, with implications for monitoring illicit drug risks.
DOI 10.1021/acschemneuro.3c00530