Pharmacology & ToxicologyScientific ReportsPeer-reviewed
Quantitative Mass Spectrometry Imaging Reveals Mutation Status-independent Lack of Imatinib Penetration into Liver Metastases of Gastrointestinal Stromal Tumors
D. Abu Sammour, C. Marsching, A. Geisel…·C. Hopf
The paper uses MSI to show imatinib does not penetrate GIST liver metastases, despite being present in healthy liver tissue, suggesting mutation-independent resistance.