High-fat diet promotes Acute Promyelocytic Leukemia through PPARδ-enhanced self-renewal of preleukemic progenitors
L. Mazzarella, P. Falvo, M. Adinolfi, G. Tini, E. Gatti, R. Piccioni, E. Bonetti, E. G. Dorronzoro, M. Bodini, B. Gallo, S. Orecchioni, B. A. Duso, C. Ronchini, A. G. Sanarico, R. Pallavi, , P. G. Pelicci
This study shows high-fat diet promotes Acute Promyelocytic Leukemia in mice by enhancing self-renewal of preleukemic progenitors through PPARδ activation, independent of genetic mutations.
bioRxiv · Mar 14, 2022Cancer Biology