Cancer BiologybioRxiv
High-fat diet promotes Acute Promyelocytic Leukemia through PPARδ-enhanced self-renewal of preleukemic progenitors
L. Mazzarella, P. Falvo, M. Adinolfi…·P. G. Pelicci
This study shows high-fat diet promotes Acute Promyelocytic Leukemia in mice by enhancing self-renewal of preleukemic progenitors through PPARδ activation, independent of genetic mutations.
DOI 10.1158/1940-6207.capr-23-0246