P. G. Pelicci

This study shows high-fat diet promotes Acute Promyelocytic Leukemia in mice by enhancing self-renewal of preleukemic progenitors through PPARδ activation, independent of genetic mutations.

The paper isolates a quiescent melanoma population in vivo, showing it has invasive properties and undergoes transcriptional reprogramming driven by the tumor niche.

This study uses ICG imaging to isolate liver micro-metastases for single-cell analysis, revealing gene expression patterns predictive of breast cancer prognosis and therapeutic targets.

This study identifies that the breast cancer pro-metastatic phenotype arises from rare clones with hyper-activation of ECM remodeling and dsRNA-IFN1 signaling, and shows these genes predict metastasis progression.

This study characterizes gPRP14 as a tumor-specific xeno-antigen that induces anti-tumor immunity in preclinical cancer models.

The paper introduces an ICS-based algorithm to evaluate STED image quality, finding that increasing STED power improves resolution but reduces contrast, while SPLIT methods enhance resolution and contrast.

The paper shows inhibiting LSD1 reduces coronavirus-induced inflammation while preserving innate antiviral activity in macrophages.

The paper analyzes pharmaceutical R&D productivity from 1990-2017, finding a recent increase in productivity despite earlier concerns about attrition rates and trial duration.