L. Mazzarella

Coexisting morpho-biotypes unveil the regulatory bases of phenotypic plasticity in pancreatic ductal adenocarcinoma

This study identifies three morpho-biotypes in PDAC and their associated gene regulatory networks, aiming to improve patient stratification and therapy.

NF1 modulates microtubule repair and sensitivity to antibody-drug conjugates

This study shows that NF1 loss increases sensitivity to the ADC T-DM1 by modulating microtubule repair and dynamics, identifying NF1 as a predictive biomarker for ADC response.

Tumor infiltrating iNKT cells sustain neutrophil pro-tumorigenic functions influencing disease progression in human colorectal cancer

The paper shows tumor-infiltrating iNKT cells have pro-tumorigenic effects in CRC by promoting neutrophil functions and poor patient outcomes.

The breast cancer pro-metastatic phenotype requires concomitant hyper-activation of ECM remodeling and dsRNA-IFN1 signaling in rare clone cells

This study identifies that the breast cancer pro-metastatic phenotype arises from rare clones with hyper-activation of ECM remodeling and dsRNA-IFN1 signaling, and shows these genes predict metastasis progression.

High-fat diet promotes Acute Promyelocytic Leukemia through PPARδ-enhanced self-renewal of preleukemic progenitors

This study shows high-fat diet promotes Acute Promyelocytic Leukemia in mice by enhancing self-renewal of preleukemic progenitors through PPARδ activation, independent of genetic mutations.

Inhibiting LSD1 suppresses coronavirus-induced inflammation but spares innate antiviral activity

The paper shows inhibiting LSD1 reduces coronavirus-induced inflammation while preserving innate antiviral activity in macrophages.