MicrobiologybioRxiv
Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry
L. Priyamvada, W. W. Kallemeijn, M. Faronato…·P. S. Satheshkumar
This study shows that IMP-1088 inhibits vaccinia virus infection by blocking N-myristoylation of viral protein L1, leading to non-infectious virions.
DOI 10.1371/journal.ppat.1010662