Spatial architecture of CD8+ T cells and DC subsets is critical for the response to immune checkpoint inhibitors in melanoma
E. Gobbini, M. Hubert, A.-C. Doffin, A. Eberhardt, L. Hermet, D. Li, P. Duplouye, S. Barrin, J. Berthet, V. Benboubker, M. Grimont, C. Sakref, J. Perrot, G. Tondeur, O. Harou, , J. Valladeau-Guilemond
This study examines the spatial organization of dendritic cell (DC) subsets and their interactions with CD8+ T cells in melanoma patients, finding that proximity between cDC1 and CD8+ T cells correlates with response to immune checkpoint inhibitors.
bioRxiv · Feb 6, 2024 · PreprintCancer Biology