The regulatory factor ELF1 triggers a critical wave of transcription in the antiviral response to type I interferon
L. L. Seifert, C. Si, S. Ballentine, D. Saha, M. de Vries, G. Wang, M. Sadic, A. Briley, U. Schaefer, H. Moulton, A. Garcia-Sastre, S. Tripathi, B. R. Rosenberg, M. Dittmann
This paper identifies ELF1 as a non-canonical regulator of antiviral ISG expression, showing it amplifies and prolongs the type I interferon response by inducing a distinct set of antiviral genes.
bioRxiv · Feb 14, 2019Immunology