G. Wang

Contrast-enhanced photon-counting micro-CT of tumor xenograft models

This study evaluates contrast agents for photon-counting micro-CT in tumor xenografts, finding that Exitrone Nano 12000 provides better vasculature enhancement and consistency compared to ISOVUE-370.

HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes

This paper introduces PRISM, a method for high-plex spatial RNA imaging using color intensity barcodes, validated across multiple tissues and showing the role of CAFs in tumor microenvironments.

Chromosome-level genome assembly of autotetraploid Selenicereus megalanthus and gaining genomic insights into the evolution of trait patterning in diploid and polyploid pitaya species

Evolutionary diversity of cell-type-specific expression and stress response in Brassicaceae roots

This study profiles root cells from five Brassicaceae species under stress treatments, revealing cell-type-specific gene expression divergence and stress response variation across species.

Oligopeptide (FK)4 facilitates the determination of the absolute stereochemistry of chiral organic compounds via NMR Spectroscopy

This study demonstrates how the oligopeptide (FK)4 enables the determination of absolute stereochemistry of chiral compounds using NMR spectroscopy by combining alignment medium and chiral differentiating properties.

Inhibitor of cardiolipin biosynthesis-related enzyme MoGep4 confers broad-spectrum anti-fungal activity

The paper identifies MoGep4 as a key enzyme in cardiolipin biosynthesis in M. oryzae, showing that its inhibitor AXD has broad-spectrum antifungal activity against plant pathogens.

CrHCF244 is required for psbA translation in Chlamydomonas reinhardtii

This study identifies CrHCF244 as a psbA translation factor in Chlamydomonas, showing functional conservation with Arabidopsis HCF244 and suggesting alternative factors exist.

Targeting PRMT3 Impairs Methylation and Oligomerization of HSP60 to Boost Anti-Tumor Immunity by Activating cGAS/STING Signaling

This study identifies PRMT3 as a driver of immunotherapy resistance in HCC, showing that targeting it enhances anti-tumor immunity via cGAS/STING activation.

Exploring differences between depression and bipolar disorder through the urinary proteome

This study identifies differential proteins in urine proteomics to distinguish depression from bipolar disorder, suggesting immune-related mechanisms and potential biomarkers for diagnosis and treatment.

Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers

This paper identifies transcription-replication conflict as a vulnerability in ecDNA-containing cancers and demonstrates that CHK1 inhibition selectively kills these tumors.

Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase

This paper identifies AhCobQ as a novel NAD+- and Zn2+-independent lysine deacetylase in Aeromonas hydrophila with unique domain and substrate specificity.

Zinc Alpha-2-Glycoprotein (ZAG/AZGP1) secreted by triple-negative breast cancer promotes tumor microenvironment fibrosis.

This study identifies ZAG/AZGP1 as a secreted factor from triple-negative breast cancer cells that promotes fibrosis in the tumor microenvironment and is linked to poor patient prognosis.

Targeting GFPT2 to reinvigorate immunotherapy in EGFR-mutated NSCLC

This study identifies GFPT2 as a metabolic checkpoint in EGFR-mutated NSCLC that promotes immune evasion, and shows that targeting GFPT2 enhances PD-1 blockade therapy.

Architecture of the spinach plastid-encoded RNA polymerase

This study presents the cryo-EM structure of the spinach plastid-encoded RNA polymerase complex, revealing its composition and spatial arrangement of subunits and associated proteins.

Supercontinuum intrinsic fluorescence imaging heralds free view of living systems

This paper introduces a supercontinuum fluorescence imaging technique that enables non-invasive, high-content analysis of living systems across multiple biological processes and species.

PRMT5 orchestrates EGFR and AKT networks to activate NFκB and promote EMT

This study identifies PRMT5's role in promoting EMT in neuroblastoma by regulating EGFR and AKT pathways, leading to NFκB activation and tumor growth.

Histone acetyltransferase HAF2 associates with PDC to control H3K14ac and H3K23ac in ethylene response

This study identifies HAF2 as a histone acetyltransferase that interacts with EIN2-C and PDC to regulate H3K14ac and H3K23ac in response to ethylene.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

Structural insights into specific recognition of PTENα/β-NTE by WDR5 in cancer progression

The paper determines the crystal structure of PTEN-NTE bound to WDR5, revealing a specific binding motif that promotes tumor growth and suggests WDR5 inhibitors as potential cancer therapies.

Development of attenuated coxsackievirus B3 vectored intranasal pre-emptive pan-coronavirus vaccine

The paper designs an intranasal pan-coronavirus vaccine using epitopes from SARS-CoV-2 and zoonotic coronaviruses, showing immune responses in mice but needing further cross-reactivity testing.

Pan-genome analysis of different morphotypes reveals genomic basis of Brassica oleracea domestication and differential organogenesis

This study constructs a pan-genome of Brassica oleracea to uncover genomic basis of domestication and organogenesis differences among morphotypes.

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

Gentle label-free nonlinear optical imaging relaxes linear-absorption-mediated triplet

The paper investigates phototoxicity in nonlinear optical imaging and proposes a technique to mitigate it using rapid sub-80-fs excitation with full triplet-relaxation.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

Decoding genetic architecture of dog complex traits by constructing fine-scale genomic ancestry of admixture

The paper develops a method to reconstruct fine-scale genomic ancestry in admixed dog breeds and identifies genes associated with body size traits.

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

High-throughput generic single-entity sequencing using droplet microfluidics

This paper introduces GSE-Seq, a high-throughput platform for single-entity sequencing that enables long-read profiling of dsDNA and ssDNA from viruses and bacteria, revealing previously overlooked dark matter and phage-host interactions.

A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis

This study identifies a pro-inflammatory stem cell niche that drives myelofibrosis via galectin 1, offering a targetable pathway for therapy.

A Gpr35 tuned gut-brain metabolic axis regulates depressive-like behavior

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.