Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression
A. Di Domenico, C. P. Pipinikas, R. S. Maire, K. Bräutigam, C. Simillion, M. S. Dettmer, E. Vassella, C. Thirlwell, A. Perren, I. Marinoni
The paper uses DNA methylation profiling to identify cell origins and progression mechanisms in PanNETs, finding distinct epigenetic clusters associated with different cell types and clinical outcomes.
bioRxiv · Apr 8, 2020Cancer Biology