Author

M. Stoffel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

G. Schwank· 2 shared P. Simmler· 2 shared A. Khales· 1 shared A. Vukolic· 1 shared C. Cortijo· 1 shared C. Hirt· 1 shared C. Mueller· 1 shared C. Pauli· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

G. Schwank

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mutant SF3B1 promotes PDAC malignancy through TGF-β resistance

P. Simmler, T. Mengis, K. Van-Lehmann, A. Khales, T. Thomas, G. Rätsch, M. Stoffel, G. Schwank

This study shows that SF3B1K700E mutation in PDAC enhances tumor aggressiveness when combined with KRAS and p53 mutations by promoting TGF-β resistance.

bioRxiv · Jun 16, 2022Cancer Biology

SF3B1 promotes tumor malignancy through splicing-independent co-activation of HIF1α

P. Simmler, C. Cortijo, L. M. Koch, P. Galliker, M. Schaefer, S. Angori, H. A. Bolck, C. Mueller, A. Vukolic, P. Mirtschink, Y. Christinat, N. R. Davidson, K.-V. Lehmann, G. Pellegrini, C. Pauli, , G. Schwank

This study shows SF3B1 promotes tumor malignancy by co-activating HIF1α through a splicing-independent mechanism, enhancing hypoxia response element binding and target gene expression.

bioRxiv · Nov 10, 2020Cell Biology

Determination of host cell proteins constituting the molecular microenvironment of coronavirus replicase complexes by proximity-labeling

P. V'kovski, M. Gerber, J. Kelly, S. Pfaender, N. Ebert, S. Braga Lagache, C. Simillion, J. Portmann, H. Stalder, V. Gaschen, R. Bruggmann, M. Stoffel, M. Heller, R. Dijkman, V. Thiel

The paper identifies host proteins near coronavirus replicase complexes using proximity-labeling and shows their roles in viral replication and host processes.

bioRxiv · Sep 14, 2018Microbiology