Author

C. Thirlwell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

C. P. Pipinikas· 2 shared A. Akarca· 1 shared A. Di Domenico· 1 shared A. Furness· 1 shared A. Lorincz· 1 shared A. Pennycuick· 1 shared A. Perren· 1 shared B. Carroll· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

C. P. Pipinikas

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3 papers

Recent·Most cited

Colorectal cancer risk in bowel adenomas based on lifestyle exposures, tissue preconditioning and DNA methylation

J. Sutton, M. Moorghen, L. M. Wang, C. Thirlwell, C. Pipinikas, A. Lorincz

This study identifies DNA methylation changes linked to high alcohol and BMI exposures in colorectal adenomas, suggesting they may increase CRC risk through tissue preconditioning.

bioRxiv · Aug 26, 2021 · PreprintCancer Biology

Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression

A. Di Domenico, C. P. Pipinikas, R. S. Maire, K. Bräutigam, C. Simillion, M. S. Dettmer, E. Vassella, C. Thirlwell, A. Perren, I. Marinoni

The paper uses DNA methylation profiling to identify cell origins and progression mechanisms in PanNETs, finding distinct epigenetic clusters associated with different cell types and clinical outcomes.

bioRxiv · Apr 8, 2020Cancer Biology

Immune surveillance in clinical regression of pre-invasive squamous cell lung cancer

A. Pennycuick, V. H. Teixeira, K. AbdulJabbar, S. E. A. Raza, T. Lund, A. Akarca, R. Rosenthal, C. P. Pipinikas, H. Lee-Six, D. P. Chandrasekharan, R. E. Hynds, K. H. C. Gowers, J. Y. Henry, C. Denais, M. Falzon, , S. M. Janes

The paper investigates immune surveillance in pre-invasive squamous cell lung cancer, finding that regressive lesions have more immune infiltration and distinct molecular profiles compared to progressive lesions.

bioRxiv · Nov 10, 2019Cancer Biology