J. Kelly

Dynamic Monitoring of Antibody Drug Conjugates Targeting TROP2 or HER2 in Breast Cancer using Circulating Tumor Cells

In metastatic breast cancer on TROP2- or HER2-targeting antibody-drug conjugates, early CTC disappearance or steep decline tracked response, while CTC epitope levels neither predicted benefit nor vanished at resistance.

AutoXAI4Omics: an Automated Explainable AI tool for Omics and tabular data

AutoXAI4Omics automates and explains ML pipelines for omics and tabular data, enabling interpretable insights for biomarker discovery and phenotype prediction.

Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product

This study uses high-throughput microfluidic technology to enrich CTCs from large blood volumes, enabling detailed molecular and morphological analysis of tumor cells in metastatic cancer patients.

PET imaging of fibroblast activation protein alpha (FAP) detects incipient cardiotoxicity due to anthracycline chemotherapy

This study shows that PET imaging with [68Ga]Ga-FAPI-04 detects early cardiotoxicity from anthracycline chemotherapy before echocardiography, by targeting fibroblast activation protein alpha (FAP).

PROTEIN-O-MANNOSYLATION BY NON-SEC/TAT SECRETION TRANSLOCONS IN ACTINOBACTERIA

This paper investigates protein-O-mannosylation in non-pathogenic actinobacteria, showing that GT-39 enzymes have different activities and that POM occurs via both SEC and TAT pathways.

Using spatio-temporal information in weather radar data to detect and track communal bird roosts

This paper develops an AI system to detect and track swallow roosts in weather radar data, improving detection performance with temporal information and reducing human effort.

Development and evaluation of statistical and Artificial Intelligence approaches with microbial shotgun metagenomics data as an untargeted screening tool for use in food production

This study evaluates AI and statistical methods on microbial shotgun metagenomics data to detect anomalies in fluid milk, showing explainable AI can classify anomalous samples and identify microbial drivers.

Pannexin 3 channels regulate architecture, adhesion, barrier function and inflammation in the skin

This study shows PANX3 is essential for maintaining skin architecture, adhesion, barrier function, and inflammation during aging, as demonstrated in knockout mice.

Membrane interactions and uncoating of Aichi virus, a picornavirus that lacks a VP4

This study investigates the role of VP0 in Aichi virus membrane interactions and uncoating, showing that pH affects genome exposure and pore formation analogous to VP4 in other picornaviruses.

Fluidics System for Resolving Concentration-Dependent Effects of Dissolved Gases on Tissue Metabolism

This paper introduces a fluidics system to study how dissolved gases affect tissue metabolism and function, revealing new insights into oxygen consumption and hydrogen sulfide effects on insulin secretion.

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

This paper describes a yeast-based synthetic genomics platform for rapid reconstruction of RNA viruses, including SARS-CoV-2, using synthetic DNA fragments and TAR cloning.

Effectiveness of protected areas in conserving tropical forest birds

The paper uses eBird data to assess how protected areas in tropical forests affect bird diversity, finding protection helps retain forest-dependent and threatened species but not overall richness.

Beyond Conventional Models: Recreating the Initiation, Evolution, and Genome of GBM

This study develops a mouse model of glioblastoma (GBM) that replicates its genomic landscape and early stages, enabling research into prevention and treatment strategies.

Immunity conferred by drug-cured experimental Trypanosoma cruzi infections is long-lasting and cross-strain protective

This study shows that drug-cured Trypanosoma cruzi infections in mice provide long-lasting, cross-strain immunity against re-infection, outperforming recombinant vaccines.

Determination of host cell proteins constituting the molecular microenvironment of coronavirus replicase complexes by proximity-labeling

The paper identifies host proteins near coronavirus replicase complexes using proximity-labeling and shows their roles in viral replication and host processes.

Identifying Migrant Origins Using Genetics, Isotopes, and Habitat Suitability

The paper develops a method combining genetics, isotopes, and habitat suitability to infer migratory origins, showing improved accuracy when integrated.