Author

S. Pfaender

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 12 Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 14 Research Focus:host-pathogen & immune response· 14 Organism:human· 5 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

D. Todt· 11 shared E. Steinmann· 9 shared T. L. Meister· 7 shared A. Krawczyk· 6 shared N. Ebert· 6 shared R. Dijkman· 6 shared V. Thiel· 6 shared A. Kratzel· 5 shared

Activity by Year

2018-2022 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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Curved chords = mutual co-authorship

11 shared papersMicrobiology

D. Todt

Mutual co-authors in cluster

Author profile →

16 papers

Recent·Most cited

Increased migratory/activated CD8+ T cell and low avidity SARS-CoV-2 reactive cellular response in post-acute COVID-19 syndrome

K. Paniskaki, M. Konik, M. Anft, H. Heidecke, T. Meister, S. Pfaender, A. Krawczyk, M. Zettler, J. Jäger, A. Gaeckler, S. Dolff, T. Westhoff, H. Rohn, U. Stervbo, C. Scheibenbogen, , N. Babel

This study identifies increased migratory CD8+ T cells and low avidity SARS-CoV-2 reactive responses in post-acute COVID-19 syndrome patients compared to healthy convalescents.

bioRxiv · Dec 3, 2022 · PreprintImmunology

SARS-CoV-2 entry route impacts a range of downstream viral and cellular processes

B. Qu, C. Miskey, A. Goemer, D. Potmus, M. Nocke, R. D. V. Kleinert, T. K. Itotia, L. Valder, J. Brueckmann, S. Hoeck, F. D. Hastert, C. von Rhein, C. Schuermann, A. Ebenig, M. Widera, , R. J. P. Brown

This study shows that SARS-CoV-2 entry via TMPRSS2 or endolysosomal cathepsins affects viral replication, immune response, and genome evolution.

bioRxiv · Aug 5, 2022 · PreprintMicrobiology

SARS-CoV-2 neutralizing camelid heavy-chain-only antibodies as powerful tools for diagnostic and therapeutic applications

A. Schloer, S. Hirschberg, G. Ben Amor, T. L. Meister, P. Arora, S. Pöhlmann, M. Hoffmann, S. Pfaender, O. Kamal Eddin, J. Kamhieh-Milz, K. Hanack

This study identifies camelid heavy-chain-only antibodies that effectively neutralize SARS-CoV-2 and its variants, showing potential for diagnostic and therapeutic applications.

bioRxiv · Mar 24, 2022Immunology

In contrast to TH2-biased approaches, TH1 COVID-19 vaccines protect Syrian hamsters from severe disease in the absence of dexamethasone-treatable vaccine-associated enhanced respiratory pathology

A. Ebenig, S. Muraleedharan, J. Kazmierski, D. Todt, A. Auste, M. Anzaghe, A. Gömer, D. Postmus, P. Gogesch, M. Niles, R. Plesker, C. Miskey, M. Gellhorn Serra, A. Breithaupt, C. Hörner, , M. D. Mühlebach

This study compares TH1 and TH2-biased vaccines in Syrian hamsters, showing that TH1 vaccines prevent severe disease without inducing VAERD, while TH2 vaccines cause VAERD through eosinophil recruitment and TH2 cytokine upregulation.

bioRxiv · Dec 28, 2021 · PreprintImmunology

Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus

M. Gultom, A. Kratzel, J. Portmann, H. Stalder, A. C. Baetzner, H. Gantenbein, C. Gurtner, N. Ebert, H. Posthaus, P. Zanolari, S. Pfaender, V. Thiel, R. Dijkman

This study establishes camelid airway epithelial cell cultures to study MERS-CoV infection and replication, showing divergent tropism and interferon inhibition.

bioRxiv · Nov 10, 2021Microbiology

Differential interferon-α subtype immune signatures suppress SARS-CoV-2 infection

J. Schuhenn, T. L. Meister, D. Todt, T. Bracht, K. Schork, J.-N. Billaud, C. Elsner, N. Heinen, Z. Karakoese, S. Haid, S. Kumar, L. Brunotte, M. Eisenacher, J. Chen, Z. Yuan, , S. Pfaender

The paper identifies differential antiviral effects of IFN-alpha subtypes against SARS-CoV-2 and highlights IFN5's superior activity, suggesting therapeutic potential.

bioRxiv · May 20, 2021 · PreprintCell Biology

Comparable environmental stability and disinfection profiles of the currently circulating SARS-CoV-2 variants of concern B.1.1.7 and B.1.351

T. L. Meister, J. Fortmann, D. Todt, N. Heinen, A. Ludwig, Y. Brueggemann, C. Elsner, U. Dittmer, S. Pfaender, E. Steinmann

This study compares the environmental stability and disinfection profiles of SARS-CoV-2 variants B.1.1.7 and B.1.351 to the wildtype, finding comparable susceptibility to disinfection and surface stability.

bioRxiv · Apr 7, 2021Microbiology

A realistic touch-transfer method reveals low risk of transmission for SARS-CoV-2 by contaminated coins and bank notes

D. Todt, T. L. Meister, B. Tamele, J. Howes, D. Paulmann, B. Becker, F. H. Brill, M. Wind, J. Schijven, B. Mhlekude, C. Goffinet, A. Krawczyk, J. Steinmann, S. Pfaender, Y. Brueggemann, E. Steinmann

This study assesses the risk of SARS-CoV-2 transmission via contaminated coins and banknotes using a novel touch transfer method and shows it is unlikely under typical conditions.

bioRxiv · Apr 2, 2021Microbiology

A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets

A. Kratzel, J. N. Kelly, Y. Brueggemann, J. Portmann, P. V'kovski, D. Todt, N. Ebert, E. Steinmann, R. Dijkman, G. Zimmer, S. Pfaender, V. Thiel

This study identifies autophagy-related host factors as conserved targets for coronavirus replication using CRISPR screens and shows that immunophilin inhibitors can block viral replication.

bioRxiv · Feb 24, 2021Microbiology

Virucidal efficacy of different formulations for hand and surface disinfection targeting SARS CoV-2

K. Steinhauer, T. L. Meister, D. Todt, A. Krawczyk, L. Passvogel, B. Becker, D. Paulmann, B. Bischoff, M. Eggers, S. Pfaender, F. Brill, E. Steinmann

This study shows that three disinfectant formulations effectively inactivate SARS-CoV-2, supporting their use as preventive measures against enveloped viruses.

bioRxiv · Nov 8, 2020Microbiology

Comparison of the in vitro-efficacy of different mouthwash solutions targeting SARS-CoV-2 based on the European Standard EN 14476

K. Steinhauer, T. L. Meister, D. Todt, A. Krawczyk, L. Passvogel, B. Becker, D. Paulmann, B. Bischoff, S. Pfaender, F. Brill, E. Steinmann

This study evaluates the in vitro efficacy of chlorhexidine and octenidine mouthwashes against SARS-CoV-2 using EN 14476 standards, finding octenidine effective within 15 seconds.

bioRxiv · Oct 25, 2020Microbiology

LY6E impairs coronavirus fusion and confers immune control of viral disease

S. Pfaender, K. B. Mar, E. Michailidis, A. Kratzel, D. Hirt, P. V'kovski, W. Fan, N. Ebert, H. Stalder, H. Kleine-Weber, M. Hoffmann, H. H. Hoffmann, M. Saeed, R. Dijkman, E. Steinmann, , V. Thiel

This study identifies LY6E as an interferon-induced gene that restricts coronavirus entry and pathogenesis by inhibiting spike protein-mediated fusion and protecting immune cells.

Nature Microbiology · Jul 23, 2020Peer-reviewedMicrobiology

Holder Pasteurization Inactivates SARS-CoV-2 in Human Breast Milk

C. Conzelmann, R. Gross, T. L. Meister, D. Todt, A. Krawczyk, U. Dittmer, S. Stenger, J. Muench, E. Steinmann, J. A. Mueller, S. Pfaender

This study shows that Holder pasteurization inactivates SARS-CoV-2 in human breast milk, offering a safe method for infected mothers to breastfeed.

bioRxiv · Jun 17, 2020 · PreprintMicrobiology

Efficient inactivation of SARS-CoV-2 by WHO-recommended hand rub formulations and alcohols

A. Kratzel, D. Todt, P. V'kovski, S. Steiner, M. L. Gultom, T. T. N. Thao, N. Ebert, M. Holwerda, J. Steinmann, D. Niemeyer, R. Dijkman, G. Kampf, C. Drosten, E. Steinmann, V. Thiel, S. Pfaender

The paper tests the virucidal activity of WHO-recommended hand rubs and alcohols against SARS-CoV-2, showing efficient inactivation for all tested products.

bioRxiv · Mar 10, 2020 · PreprintMicrobiology

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

T. T. N. Thao, F. Labroussaa, N. Ebert, P. V'kovski, H. Stalder, J. Portmann, J. Kelly, S. Steiner, M. Holwerda, A. Kratzel, M. Gultom, L. Laloli, L. Huesser, M. Wider, S. Pfaender, , V. Thiel

This paper describes a yeast-based synthetic genomics platform for rapid reconstruction of RNA viruses, including SARS-CoV-2, using synthetic DNA fragments and TAR cloning.

bioRxiv · Feb 21, 2020Microbiology

Determination of host cell proteins constituting the molecular microenvironment of coronavirus replicase complexes by proximity-labeling

P. V'kovski, M. Gerber, J. Kelly, S. Pfaender, N. Ebert, S. Braga Lagache, C. Simillion, J. Portmann, H. Stalder, V. Gaschen, R. Bruggmann, M. Stoffel, M. Heller, R. Dijkman, V. Thiel

The paper identifies host proteins near coronavirus replicase complexes using proximity-labeling and shows their roles in viral replication and host processes.

bioRxiv · Sep 14, 2018Microbiology