Cancer BiologybioRxiv
Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer
S. A. Hutchinson, A. Websdale, P. Lianto…·J. L. Thorne
This study identifies LXRalpha as a driver of chemoresistance in TNBC through its regulation of P-glycoprotein, linking cholesterol metabolism to chemotherapy failure.
DOI 10.1038/s41388-021-01720-w