Author

C. T. Appleton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Chandrabalan· 1 shared A. Firth· 1 shared A. Getgood· 1 shared A. J. Knights· 1 shared A. R. Maher· 1 shared B. Fiset· 1 shared E. C. Farrell· 1 shared E. R. Gillies· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Chandrabalan

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3 papers

Recent·Most cited

Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis

A. J. Knights, E. C. Farrell, O. M. Ellis, M. J. Song, C. T. Appleton, T. Maerz

This study identifies synovial macrophage subpopulations and their regulation by M-CSF signaling in a mouse model of post-traumatic osteoarthritis.

bioRxiv · Oct 3, 2023Immunology

Synovial macrophage activation mediates pain experiences in experimental knee osteoarthritis

G. Blackler, Y. Lai-Zhao, J. Klapak, H. T. Philpott, K. K. Pitchers, A. R. Maher, B. Fiset, L. A. Walsh, E. R. Gillies, C. T. Appleton

The study shows that targeting synovial macrophages via STAT6 inhibition reduces pain in experimental knee OA without worsening joint damage.

bioRxiv · Apr 25, 2023Physiology

Identification of Proteinase Activated Receptor (PAR) cleaving enzymes in human osteoarthritis knee joint synovial fluids.

A. Chandrabalan, A. Firth, R. B. Litchfield, C. T. Appleton, A. Getgood, R. Ramachandran

This study identifies serine proteinases and matrix metalloproteinases as major PAR activating enzymes in OA synovial fluids, suggesting potential therapeutic targets for OA.

bioRxiv · Oct 21, 2020 · PreprintPharmacology & Toxicology