Author

A. Firth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

H. Stewart· 2 shared K. Brown· 2 shared A. A. Peden· 1 shared A. Chandrabalan· 1 shared A. Getgood· 1 shared A. M. Dinan· 1 shared A. Pate· 1 shared C. T. Appleton· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

H. Stewart

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A novel ilarvirus protein is expressed via stop codon readthrough and suppresses RDR6-dependent RNA silencing

N. Lukhovitskaya, A. Firth, K. Brown, L. Hua, A. Pate, J. Carr

This study identifies a novel ilarvirus protein, CP-RT, produced via stop codon readthrough, which suppresses RNA silencing and is essential for persistent infection.

bioRxiv · Feb 8, 2024Plant Biology

Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic

H. Stewart, R. Palmulli, K. H. Johansen, N. McGovern, O. M. Shehata, G. W. Carnell, H. K. Jackson, J. S. Lee, J. C. Brown, T. C. Burgoyne, J. L. Heeney, K. Okkenhaug, A. Firth, A. A. Peden, J. R. Edgar

This study shows SARS-CoV-2 evades tetherin restriction by multiple mechanisms, including ORF3a disrupting tetherin localization and Spike protein reducing tetherin levels, enhancing viral release.

bioRxiv · Jan 6, 2021Cell Biology

Identification of Proteinase Activated Receptor (PAR) cleaving enzymes in human osteoarthritis knee joint synovial fluids.

A. Chandrabalan, A. Firth, R. B. Litchfield, C. T. Appleton, A. Getgood, R. Ramachandran

This study identifies serine proteinases and matrix metalloproteinases as major PAR activating enzymes in OA synovial fluids, suggesting potential therapeutic targets for OA.

bioRxiv · Oct 21, 2020 · PreprintPharmacology & Toxicology

The transcriptional and translational landscape of equine torovirus

H. Stewart, K. Brown, A. M. Dinan, N. Irigoyen, E. J. Snijder, A. Firth

This study analyzes the transcription and translation of equine torovirus using RNA-seq and Ribo-seq, identifying novel open reading frames and subgenomic RNA synthesis mechanisms.

bioRxiv · Apr 7, 2018Microbiology