Novel insights into the mode of action of 1,4-dioxane using a systems screening approach
V. Vasiliou, G. Charkoftaki, J. P. Golla, A. Santos-Neto, D. J. Orlicky, R. Garcia-Milian, Y. Chen, N. J. W. Rattray, Y. Cai, Y. Wang, C. T. Shern, V. Mironova, Y. Wang, C. H. Johnson, D. C. Thompson
This study investigates the toxic effects of 1,4-dioxane in mice using histopathology and multi-omics approaches, finding DNA damage counterbalanced by repair mechanisms with no systemic metabolic impact.
bioRxiv · Dec 27, 2020 · PreprintPharmacology & Toxicology