MicrobiologybioRxiv
HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-kB/IRF3 nuclear transport
H. Khan, R. P. Sumner, J. Rasaiyaah…·G. J. Towers
This study shows HIV-1 Vpr inhibits IRF3 and NF-κB nuclear transport by interacting with karyopherins, thereby evading innate immune activation and promoting HIV-1 replication in macrophages.
DOI 10.7554/elife.60821