Author

R. P. Sumner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Research Focus:phylogenetics / evolution· 1 Assay:proteomics· 1

Frequent Co-Authors

G. J. Towers· 4 shared C. Maluquer de Motes· 3 shared L. Zuliani-Alvarez· 2 shared A. Ahmad· 1 shared A. Akinpelu· 1 shared A. Ellis· 1 shared A. Rambaut· 1 shared A. Yinka-Ogunleye· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersMicrobiology

G. J. Towers

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Type I IFN expression is inhibited during cell division by CDK4/6

R. P. Sumner, A. Ellis, S. Lant, H. Ashby, G. J. Towers, C. Maluquer de Motes

The paper shows that CDK4/6 inhibition enhances DNA- or cGAMP-induced IFN and ISG expression by limiting IFNβ mRNA production during cell division.

bioRxiv · Apr 15, 2023 · PreprintImmunology

A maturation defective HIV-1 activates cGAS

R. P. Sumner, H. Blest, M. Lin, C. Maluquer de Motes, G. J. Towers

The paper shows that a maturation-defective HIV-1 variant activates the cGAS pathway, leading to an IFN response due to exposed viral DNA.

bioRxiv · Apr 14, 2023 · PreprintMicrobiology

Different Coexisting Mpox Lineages Were Continuously Circulating in Humans Prior to 2022

N. D. Ndodo, J. Ashcroft, K. Lewandowski, A. Yinka-Ogunleye, C. Chukwu, A. Ahmad, D. King, A. Akinpelu, C. Maluquer de Motes, P. Ribeca, R. P. Sumner, A. Rambaut, M. Chester, T. Maishman, O. Bamidele, , D. Ulaeto

The paper identifies multiple coexisting Mpox lineages circulating in humans in Nigeria prior to the 2022 global outbreak, showing sustained human-to-human transmission and genetic changes.

bioRxiv · Jan 3, 2023 · PreprintMicrobiology

HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-kB/IRF3 nuclear transport

H. Khan, R. P. Sumner, J. Rasaiyaah, C. P. Tan, M. T. Rodriguez-Plata, C. Van Tulleken, D. Fink, L. Zuliani-Alvarez, L. Thorne, D. Stirling, R. S. B. Milne, G. J. Towers

This study shows HIV-1 Vpr inhibits IRF3 and NF-κB nuclear transport by interacting with karyopherins, thereby evading innate immune activation and promoting HIV-1 replication in macrophages.

bioRxiv · Feb 22, 2020Microbiology

Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA

R. P. Sumner, L. Harrison, E. Touizer, T. P. Peacock, M. Spencer, L. Zuliani-Alvarez, G. J. Towers

The paper shows that disrupting HIV-1 capsid formation exposes viral DNA to cGAS, triggering an IFN response in macrophages.

bioRxiv · Nov 11, 2019Microbiology