N. Coudray

MetFinder: a neural network-based tool for automated quantitation of metastatic burden in histological sections from animal models

MetFinder uses a deep neural network to automate metastasis burden quantification in histological sections from mouse models, improving throughput and resolution compared to current methods.

Blueprinting expandable nanomaterials with standardized protein building blocks

This paper introduces standardized protein building blocks and geometric design principles to create expandable protein nanomaterials, validated through X-ray crystallography and electron microscopy.

Protein-protein interactions in the Mla lipid transport system probed by computational structure prediction and deep mutational scanning

The paper maps protein-protein interactions in the Mla lipid transport system using deep mutational scanning and AlphaFold2 structure predictions, revealing overlapping binding sites on MlaC.

Role of Ring6 in the function of the E. coli MCE protein LetB

This study investigates the role of MCE domains in LetB, an E. coli protein, finding that deletion of Ring3 or Ring6 increases resistance to membrane perturbing agents and revealing a model for tunnel gating.

Targeting Allostery in the Dynein Motor Domain with Small Molecule Inhibitors

This study develops small molecule inhibitors targeting allostery in dynein motor domains by inhibiting regulatory ATPase sites rather than the main catalytic site.

A Deep Learning Approach for Rapid Mutational Screening in Melanoma

This paper develops a deep learning model to detect BRAF mutations in melanoma histopathology images using whole slide images from 256 patients, achieving AUC scores of 0.96 and 0.72.

The transition state and regulation of γ-TuRC-mediated microtubule nucleation revealed by single molecule microscopy

This study uses single molecule microscopy to reveal how γ-TuRC nucleates microtubules, showing a cooperative mechanism involving 4 β-tubulin dimers and the role of XMAP215 in enhancing nucleation efficiency.

Structure of bacterial phospholipid transporter MlaFEDB with substrate bound

The paper reports the cryo-EM structure of the MlaFEDB complex with bound phospholipids, revealing its transport mechanism and substrate binding.

Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation

The paper reports the X-ray structure of MlaFB from E. coli, revealing how the regulatory subunit MlaB stabilizes the nucleotide binding domain and how the C-terminal tail of MlaF mediates dimerization and complex assembly.

Structure of LetB reveals a tunnel for lipid transport across the bacterial envelope

The paper determines the structure of LetB, showing it forms a hydrophobic tunnel for lipid transport across the bacterial envelope.

Efficient pan-cancer whole-slide image classification and outlier detection using convolutional neural networks

This paper introduces a simplified CNN architecture for efficient pan-cancer whole-slide image classification and outlier detection.

Coupling of ATPase activity, microtubule binding and mechanics in the dynein motor domain

This study identifies mutations in dynein's stalk that disrupt directional motion and reveal the role of the stalk in coupling conformational changes across the AAA ring.

Classification and Mutation Prediction from Non-Small Cell Lung Cancer Histopathology Images using Deep Learning

This study uses deep learning to classify lung cancer subtypes and predict gene mutations from histopathology images, achieving high accuracy and outperforming human pathologists.