Synthetically engineered IgG1 antibody Fc fragments presenting influenza A virus receptor sialic acid inhibit viral haemagglutination activity, but enhance virus replication in cultured A549 cells
R. J. Pleass, E. R. Gaunt, P. Blundell, C. Vrettou
The paper synthesizes sialylated Fc fragments that inhibit influenza A virus haemagglutination but enhance viral replication in A549 cells, suggesting unintended pro-inflammatory effects.
bioRxiv · Oct 6, 2022 · PreprintImmunology