S. Jayaraman

A Genetically Encoded Actuator Selectively Boosts L-type Calcium Channels in Diverse Physiological Settings

This paper develops GeeC, a genetically encoded actuator that boosts L-type CaV1.2/1.3 channel function in cardiomyocytes and neurons, enhancing calcium influx and excitation-transcription coupling.

Greater breadth of vaccine-induced immunity in females than males is mediated by increased antibody diversity in germinal center B cells

This study shows that female mice have stronger and more diverse antibody responses to influenza vaccination, leading to better protection against mutant viruses due to increased germinal center B cell activity.

Transplantation Elicits a Clonally Diverse CD8+ T Cell Response That is Comprised of Potent CD43+ Effectors

This study identifies CD43+ effector CD8+ T cells as potent responders after transplantation, showing their distinct profile and the importance of CD43 and ICOS in graft survival.

Jaagsiekte sheep retrovirus infection induces changes in microRNA expression in the ovine lung

This study identifies differentially expressed microRNAs in JSRV-infected ovine lung, showing upregulation of miR-182, miR-183, miR-96, and miR-135b, which are associated with oncogenic pathways in human lung cancer.

Prevalence, persistence, and genetics of antibody responses to protein toxins and virulence factors

The paper uses PhIP-Seq with a ToxScan library to profile antibody responses to toxins and virulence factors in 1,000 individuals, finding MHC-II locus associations and novel anti-flagellin links to juvenile dermatomyositis.

Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells.

The paper identifies and characterizes influenza NP-specific CD8 T cells in porcine tissues, showing their persistence and gene expression changes in the lung.

Epigenetic reprogramming ameliorates type 1 diabetes by decreasing the generation of Th1 and Th17 subsets and restoring self-tolerance in CD4+ T cells

This study shows that the histone modifier TSA reduces Th1 and Th17 cell generation and restores self-tolerance in CD4+ T cells, ameliorating type 1 diabetes in NOD mice.

Epigenetic modulation of selected immune response genes and altered functions of T lymphocytes and macrophages collectively contribute to autoimmune diabetes protection.

This study shows that TSA treatment reduces T cell and macrophage infiltration and alters gene expression in NOD mice, contributing to autoimmune diabetes protection.

Neutralizing IFNL3 Autoantibodies in Severe COVID-19 Identified Using Molecular Indexing of Proteins by Self-Assembly

MIPSA identifies neutralizing IFNL3 autoantibodies in severe COVID-19 patients by profiling autoantibodies against DNA-barcoded proteins.

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential drug sensitivity

This study compares metabolism between Trypanosoma congolense and T. brucei, finding differences in glucose uptake, glycolytic endpoints, and drug sensitivity.

Identification and phenotype of MAIT cells in cattle and their response to bacterial infections

This study identifies and characterizes MAIT cells in cattle, showing their functional response to bacterial infections and their enrichment in mucosal tissues.

Diminazene resistance in Trypanosoma congolense is linked to reduced mitochondrial membrane potential and not to reduced transport capacity

This study investigates diminazene resistance in Trypanosoma congolense and finds that resistance is due to reduced mitochondrial membrane potential rather than reduced drug transport capacity.

Do M-cells contribute significantly in T-wave morphology during normal and arrhythmogenesis conditions like short QT Syndrome?

This study uses a computational model to investigate how M-cells influence T-wave morphology and arrhythmogenesis in short QT syndrome 2.

Detecting Direct Oral Anticoagulants in Trauma Patients using Liquid Chromatography-Mass Spectrometry: a Novel Approach to Medication Reconciliation

This paper develops an LCMS-based assay to detect DOACs in trauma patients, achieving high accuracy and identifying potential medication reconciliation issues.