Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers
I. W. Dean, C. Y. Lee, Z. K. Tuong, Z. Li, C. A. Tibbitt, C. Willis, F. Gaspal, B. C. Kennedy, V. Matei-Rascu, R. Fiancette, C. Nordenvall, U. Lindforss, S. M. Baker, C. Stockmann, V. Sexl, , D. R. Withers
This study shows that conventional NK cells rapidly lose effector functions upon entering tumors and that IL-15:IL-15Ra complexes can restore their function and tissue-residency.
bioRxiv · Aug 10, 2023Immunology