C. C. Smith

A high resolution model of the grapevine leaf morphospace predicts synthetic leaves

The paper develops a high-resolution morphospace model of grapevine leaves to predict synthetic leaves and improve classification accuracy.

Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk Stratification

The paper uses multiomic single-cell profiling to show MPAL blasts have a stem-like transcriptional profile linked to poor prognosis and develops a gene score for clinical risk stratification.

Gene expression and alternative splicing contribute to adaptive divergence of ecotypes

The paper investigates how gene expression and alternative splicing contribute to adaptation in dune-adapted prairie sunflowers, showing gene-level differentiation and disrupted coexpression networks between ecotypes.

Allosteric SHP2 Inhibition Increases Apoptotic Dependency on BCL2 and Synergizes with Venetoclax in FLT3- and KIT- Mutant AML

This study shows that combining SHP2 and BCL2 inhibition synergistically kills FLT3- and KIT-mutant AML cells and xenografts.

Structural surfaceomics reveals an AML-specific conformation of Integrin-β2 as a CAR-T therapy target

The paper identifies an AML-specific conformation of Integrin-β2 using structural surfaceomics and demonstrates its targeting by CAR-T cells.

LENS - Landscape of Effective Neoantigens Software

LENS identifies tumor-specific and tumor-associated antigens from diverse genomic sources in cancer samples, expanding epitope discovery beyond somatic variants.

A SARS-CoV-2 peptide vaccine which elicits T-cell responses in mice but does not protect against infection or disease

This study evaluates a SARS-CoV-2 peptide vaccine in mice, finding it induces T-cell responses but fails to prevent infection or disease.

Aberrant regulation of RNA splicing in sunflower hybrids may underlie intrinsic incompatibilities

The paper identifies novel splice forms in sunflower hybrids that may contribute to reproductive incompatibilities through co-evolution of spliceosomal components.

Landscape and Selection of Vaccine Epitopes in SARS-CoV-2

This study identifies vaccine epitopes in SARS-CoV-2 by combining computational T cell epitope prediction, B cell epitope mapping, and manufacturability criteria to propose candidate peptides for further testing.

Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia

This study introduces DAb-seq, a method to simultaneously profile DNA and protein in single cells, and applies it to analyze leukemia patient data to reveal genotype-phenotype dynamics.

Landscape genomics of an obligate mutualism: discordant population structures between a leafcutter-ant and its fungal cultivars

This study examines landscape genomics of a leafcutter ant and its fungal cultivars, finding discordant population structures between the host and symbiont due to differences in genetic drift and gene flow.

Structure, and culture and predicted function of the gut microbiome of the Mormon cricket Anabrus simplex

The paper analyzes the gut microbiome structure of the Mormon cricket, identifying key bacterial phylotypes and their distribution across gut regions, and suggests environmental exchange of microbes.