Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells
R. Parker, T. Partridge, C. Wormald, R. Kawahara, V. Stalls, M. Aggelakopoulou, J. Parker, R. Powell Doherty, Y. Ariosa-Morejon, E. Lee, K. Saunders, B. F. Haynes, P. Acharya, M. Thaysen-Andersen, P. Borrow, N. Ternette
The paper identifies HLA-II-bound peptides from SARS-CoV-2 spike protein presented by dendritic cells, revealing glycan trimming and a receptor-binding motif-rich region for vaccine design.
bioRxiv · Aug 19, 2020Immunology