N. Ternette

Interferon-α promotes neo-antigen formation andpreferential HLA-B-restricted antigen presentation in pancreatic β-cells

This study shows that IFN-α increases HLA-B-restricted antigen presentation in pancreatic β-cells, potentially influencing T1D pathogenesis.

Identification of neoantigens in esophageal adenocarcinoma

This study identifies neoantigens in esophageal adenocarcinoma, finding one directly presented HLA-I neoantigen and a predicted HLA-II neoantigen with T-cell responses, highlighting challenges in neoantigen detection.

Minor differences in peptide presentation between chicken MHC class I molecules can explain differences in disease susceptibility

The paper shows that differences in peptide binding between chicken MHC class I alleles BF2*1901 and BF2*1501 explain their differing susceptibility to Mareks disease.

The viral vectored vaccine targeting Thymosin β10 controls tumour growth in a murine model of prostate cancer

This study uses immunopeptidomic analysis to identify peptides overexpressed in murine prostate cancer and evaluates a viral vectored vaccine targeting Thymosin β10 for tumour growth control in a TRAMP model.

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

The paper identifies HLA-II-bound peptides from SARS-CoV-2 spike protein presented by dendritic cells, revealing glycan trimming and a receptor-binding motif-rich region for vaccine design.

Elucidation of the signatures of proteasome-catalysed peptide splicing

This study defines the biochemical constraints of proteasome-catalysed cis-splicing reactions through in vitro experiments and mass-spectrometry-based sequencing, revealing sequence- and size-dependent splicing signatures.

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-presentation and CD8 T Cell Responses

This study identifies TBK1 and PI31 as key mediators of NOD2 and TLR2 signaling in dendritic cells, enhancing cross-presentation and CD8+ T cell responses against bacterial pathogens.

Improved prediction of Bovine Leucocyte Antigens (BoLA) presented ligands by use of MS eluted ligands and in-vitro binding data; impact for the identification T cell epitopes

The paper improves BoLA-I T cell epitope prediction by integrating MS ligand data with in-vitro binding data using a novel pipeline.