K. Saunders

Altered inflammatory state and mitochondrial function identified by transcriptomics in paediatric congenital heart patients prior to surgical repair

This study identifies altered mitochondrial function and increased inflammatory T cell markers in paediatric CHD patients before surgery using transcriptomic analysis of RV biopsies.

Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

This study shows non-neutralizing SARS-CoV-2 antibodies protect mice from severe disease via Fc-mediated effector functions, reducing viral load and lung damage.

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

This study shows that vaccinating macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural features of CD4-mimicking antibodies.

Organoid generation from mouse mammary tumors captures the genetic heterogeneity of clinically relevant copy number alterations

The paper identifies copy number amplifications in metastatic breast tumors and validates FGFR1 amplification in migrating organoids, showing organoids capture tumor genetic heterogeneity.

The chemical synthesis of knob domain antibody fragments

This paper demonstrates the chemical synthesis of knob domain antibody fragments, showing structural equivalence to biological products and highlighting methods to improve their stability and efficacy.

Frequent development of broadly neutralizing antibodies in early life in a large cohort of HIV-infected children

This study finds that HIV-infected children aged 1-3 years develop broadly neutralizing antibodies with breadth comparable to adults, and overall higher than adults, suggesting early life immune advantages for HIV vaccine development.

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

The paper identifies HLA-II-bound peptides from SARS-CoV-2 spike protein presented by dendritic cells, revealing glycan trimming and a receptor-binding motif-rich region for vaccine design.

Cold sensitivity of the SARS-CoV-2 spike ectodomain

The paper shows that the SARS-CoV-2 spike ectodomain construct 2P is cold-sensitive, and this sensitivity is resolved in a down-state stabilized spike.