P. Borrow

HLA-E-VL9 antibodies enhance NK cell and CD8+ T cell cytotoxicity against HIV-infected CD4+ T cells

This study develops anti-HLA-E-VL9 antibodies that enhance NK and CD8+ T cell cytotoxicity against HIV-infected cells by blocking NKG2A/CD94 interactions and promoting ADCC.

Circadian regulation of human immunodeficiency virus type 1 replication

This study shows HIV-1 replication is regulated by circadian rhythms through interactions between transcription factors BMAL1, REV-ERB, and ROR, with implications for HIV therapy.

Regulation of the cell surface expression of classical and non-classical MHC proteins by the human cytomegalovirus UL40 and rhesus cytomegalovirus Rh67 proteins

This paper shows that UL40 and Rh67 proteins from CMV replace endogenous VL9 peptides to up-regulate MHC-E expression, enabling immune evasion by NK cells.

Mapping the epitopes of the Human Leukocyte Antigen E antibodies 3D12 and 4D12

This study maps the epitopes of antibodies 3D12 and 4D12 that bind to HLA-E, revealing distinct binding regions on the alpha 3 and alpha 2 domains.

Mouse and Human Antibodies that Bind HLA-E-Leader Peptide Complexes and Enhance NK Cell Cytotoxicity

The paper isolates antibodies that bind HLA-E-Leader peptide complexes and enhance NK cell cytotoxicity in both mice and humans.

HLA-E restricted, HIV-1 suppressing, Gag specific CD8+ T cells offer universal vaccine opportunities

The paper demonstrates that HLA-E restricted, HIV-1 specific CD8+ T cells can suppress HIV-1 replication in vitro, suggesting potential for a universal vaccine.

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

The paper identifies HLA-II-bound peptides from SARS-CoV-2 spike protein presented by dendritic cells, revealing glycan trimming and a receptor-binding motif-rich region for vaccine design.

Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication

This study shows that REV-ERB agonists inhibit HIV-1 replication by suppressing its promoter activity in multiple cell types.

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

Elucidation of the signatures of proteasome-catalysed peptide splicing

This study defines the biochemical constraints of proteasome-catalysed cis-splicing reactions through in vitro experiments and mass-spectrometry-based sequencing, revealing sequence- and size-dependent splicing signatures.

Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity

This study identifies novel ISGylation targets regulated by USP18, showing its role in enhancing tumour cell antigenicity and reducing radiosensitivity in CML cells.

cGAMP loading enhances the immunogenicity of VLP vaccines

This study shows that incorporating cGAMP into virus-like particles (VLPs) enhances their immunogenicity, leading to stronger T cell responses and antibody titres against HIV and influenza viruses.

IL-15 re-programming compensates for NK cell mitochondrial dysfunction in HIV-1 infection

This study shows that IL-15 treatment improves NK cell function in HIV-1 infection by enhancing mTORC1 activity and compensating for mitochondrial dysfunction.

Subordinate effect of -21M HLA-B dimorphism on NK cell repertoire diversity and function in HIV-1 infected individuals of African origin

This study examines the effect of HLA-B -21M dimorphism on NK cell diversity and function in HIV-1/HCMV co-infected African individuals, finding no significant correlation with HLA-E abundance or functional advantage.

CD4+ T follicular helper (Tfh) cells in human tonsil and blood are clonally convergent, but divergent from non-Tfh CD4+ cells

The paper examines clonal relationships between Tfh cells in blood and tonsil, finding clonal convergence between peripheral and tonsillar Tfh cells but divergence from non-Tfh CD4+ cells.